Endocrine Abstracts

Background: The burden and management of Addison’s disease (AD) in Africa have not been well documented. We aimed to identify specific disease characteristics, patient demographics and patterns of clinical management in established AD in Africa, hypothesizing that deficiencies in diagnosis and management exist.Methods: An on-line survey of a large pool of medical practitioners’ experience from Africa and Middle East, relating to AD was conduc...

Introduction: The defecatory strain in constipated people can raise the blood pressure and occasionally trigger cardiovascular events.Methods: Review of the patient’s clinical records and the relevant literature.Results: Clinical Case: A 53-year old woman with history of breast surgery for adenocarcinoma and chronical constipation had severe resistant hypertension in the previous three years; she had hypertensive crises with ...

Objective: Cushing’s disease (CD) is difficult to diagnose because of its rarity and because its most common symptoms can overlap with those of other more common conditions. Remission rates in the postoperative vary between 55–85%. Overall, the mean time to diagnosis was 38 months. The objective of this study was to describe whether there is any pre-surgical clinical data that predicts CD remission after TSS.Patients and Methods: Retrospectiv...

Objective: Remission of Cushing’s disease (CD) in the postoperative vary between 55–85%, recurrence of up to 25%. Remission and recurrence rates vary dependent on tumor size and neurosurgical expertise. The objective of this study is to describe whether there are clinical data that help us to predece recurrence of CD after transsphenoidal surgery (TSS).Patients and Methods: Retrospective analysis of patients who underwent as TSS for CD. Varia...

Introduction: Turner’s syndrome (TS) affects 1/2500 female births and it is characterized by growth retardation, dysmorphic syndrome and gonadal dysgenesis. Our objective was to describe the clinical, therapeutic and evolutive features of Tunisian patients with TS.Patients and Methods: It was a retrospective study including 23 patients with TS diagnosed between 1993 and 2019.We noted clinical, therapeutic and evolutive data for each patient.<p ...

Medullary Thyroid Carcinoma (MTC) can be associated with Hirschsprung’s disease (HSCR). Mutations in exon 10 of the RET proto-oncogene were found in patients with co-occurrence of HSCR and MTC. The aim of the study was to screen the MTC risk exons in patients with HSCR. The genetic analysis comprised 73 HSCR patients (53 males, 20 females) who were operated on and followed-up during 2001-2006. The cohort consisted of 48 patients with classical HSCR, 11 with long colonic a...

Hashimoto’s thyroiditis (HT) is usually characterized by goiter and/or hypothyroidism. Thyroid pain and tenderness are rare and suggest an alternative diagnostic of subacute thyroiditis (SAT).We present two cases of painful HT, who had temporary relief with corticosteroids and required surgical intervention for persistent pain. Both patients were middle-aged women with painful goiter, fever, and inflammatory syndrome. Thyroid function was normal, an...

Glucose metabolism was investigated in 65 patients with Cushing’s syndrome (CS), 19 with cortisol-secreting adrenal adenoma (mean age 47.2±4.9), 40 with ACTH secreting pituitary adenoma (mean age 41.4±12.48), 4 with cortisol secreting adrenal cancer (mean age 63.0±8.4) and 2 patients with ectopic ACTH secretion (38.7±11.9).Eleven patients (17%) were diagnosed as diabetic after abnormal fasting glucose levels (>126 mg/dl). Whi...

Hashimoto’s thyroiditis (HT) is the most frequent thyroid disease in children, in areas of the world with sufficient iodine intake.Aim: To study the clinical features of HT in children at presentation.Material and method: We studied 99 children with HT, 76 (76.8%) girls and 23 (23.2%) boys, with mean chronological age 10.7±2.6 ys (3.2–15.6 ys). The diagnosis of HT was established from the high titers of antithyroid a...

BackgroundCushing’s disease (CD) is caused by high levels of blood cortisol resulting from excess secretion of adrenocorticotropic hormone (ACTH) from an anterior pituitary corticotroph adenoma. Clinical manifestations include diabetes, hypertension, osteoporosis, and depression. If untreated, CD has an increased mortality of five-fold owing to cardiovascular comorbidities, stroke or raised vulnerability to infection. Currently, transsphenoidal surg...